Cancer

Cancer Hotspot Panel v2

50 genes covering ~207 mutation hotspots across well-characterized oncogenes and tumor suppressors.

Panel details

50 genes · default amplicon 200 bp · 2 pools

Modelled on the Ion AmpliSeq Cancer Hotspot Panel v2 — the most widely-cited starter panel for somatic cancer variant detection. Covers the canonical drivers (TP53, KRAS, BRAF, PIK3CA, EGFR, …) plus a curated set of context genes useful across solid tumors. Use it as a starting point for clinical research, then trim or extend the gene list to match your study.

Gene list (50)

ABL1AKT1ALKAPCATMBRAFCDH1CDKN2ACSF1RCTNNB1EGFRERBB2ERBB4EZH2FBXW7FGFR1FGFR2FGFR3FLT3GNA11GNAQGNASHNF1AHRASIDH1IDH2JAK2JAK3KDRKITKRASMETMLH1MPLNOTCH1NPM1NRASPDGFRAPIK3CAPTENPTPN11RB1RETSMAD4SMARCB1SMOSRCSTK11TP53VHL

ClinVarCOSMICAmpliSeq CHPv2 (Ion Torrent)

Use this panel

Clone the panel into a new design wizard — pre-populated with the full gene list, amplicon size, and pool count. You can edit any of those before submitting.

Start from scratch